Gentamycin belongs to the group of aminoglycosides and acts bactericidal against mainly Gram-negative bacteria like E. coli, Klebsiella, Pasteurella and Salmonella spp. The bactericidal action is based on inhibition of bacterial protein synthesis by binding to ribosomal sub units.
Aminoglycoside antibiotic:
Used for a variety of gram-negative bacterial infections as well as synergistically for gram-positive bacterial infections, such as endocarditis.
Major toxicities include nephrotoxicity, ototoxicity, neurotoxicity; careful patient monitoring is suggested. Available in a variety of dosage forms to be used topically, via ophthalmic route, and as systemic parenteral therapy.